Alzheimer Aβ disrupts the mitotic spindle and directly inhibits mitotic microtubule motors
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چکیده
منابع مشابه
Alzheimer Aβ disrupts the mitotic spindle and directly inhibits mitotic microtubule motors.
Chromosome mis-segregation and aneuploidy are greatly induced in Alzheimer's disease and models thereof by mutant forms of the APP and PS proteins and by their product, the Ab peptide. Here we employ human somatic cells and Xenopus egg extracts to show that Aβ impairs the assembly and maintenance of the mitotic spindle. Mechanistically, these defects result from Aβ's inhibition of mitotic motor...
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ژورنال
عنوان ژورنال: Cell Cycle
سال: 2011
ISSN: 1538-4101,1551-4005
DOI: 10.4161/cc.10.9.15478